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Conversely, hepatocytes with acquired O-GlcNAc modification exhibited reduced necroptosis and liver fibrosis, indicating that OGT has the potential to inhibit necroptosis in hepatocytes and suppress the advancement of liver fibrosis

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In some embodiments, the otic formulations or compositions described herein deliver an active agent to the external, middle and/or inner ear, including the cochlea and vestibular labyrinth